Neutrophils are the most important circulating phagocytes. Circulating monocytes\nand precursors of tissue macrophages also have the ability to phagocytize.\nPidotimod (ADIMODââ??¢) exerts immunostimulatory and immunoregulatory\neffects through the stimulation and regulation of cellular immune responses\nby lymphocytes Canine herpesvirus (CHV) mainly affect puppies between\nthe first and second weeks of age, causing high morbidity in the litter.\nTo date, there is only one commercial vaccine in Europe to prevent disease. In\nthis work, inactivated CHV cultures were inoculated in rabbits, adsorbed and\nnot adsorbed to chitosan nanoparticles. Phagocytosis in the presence or absence\nof specific antibodies was measured. Response of virus neutralizing antibodies\nwas also evaluated. Adimodââ??¢ enhanced the nonspecific and specific\nphagocytotic response. The association of the virus to the nanoparticles increased\nthe phagocytic ability of blood cells; however, Adimodââ??¢ alone had a\ngreater effect on phagocytic activity and generated a stronger immune response\nthat corresponded to the increased phagocytosis (p < 0.05). Moreover,\nthe level of neutralizing antibodies was higher and increased more rapidly\nwhen Adimodââ??¢ was used.
Loading....